Syria recognized the state independence of Ukraine on December 28, 1991.
On March 31, 1992 Ukraine and Syria signed a Protocol on establishment of diplomatic relations and Agreement on cooperation and coordination between the Ministry of Foreign Affairs of Ukraine and the Ministry of Foreign Affairs of Syria.
Embassy of Ukraine opened in Damascus in February 2000.
In February 2002 Honorary Consulate of Ukraine opened in Aleppo.
Embassy of the Syrian Arab Republic opened in Ukraine in August 2004.